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Cytokines (IL-1α, IL-6 and TNF-α) exerted a specific timely-dependent regulation of DME expression (CYP1A1, CYP1A2 and CYP3A4) and secretion of acute phase reactants (albumin, ferritin, fibrinogen and ceruloplasmin) in cultured primary human hepatocytes.
These results indicate that PKG-CA exerted a specific, inhibitory action on the function of cardiac-type KATP channels expressed in HEK293 cells, which became evident only in cell-free patches (Fig. 2A,B,E) but not in intact cells.
For example, MYB28, 29 and 76 exerted a specific and coordinated control on the regulation of aliphatic GS biosynthesis, while MYB34, 51 and 122 could regulate the synthesis of indolic GS [ 49, 50].
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To assess whether IVmethylprednisolone exerts a specific early effect on dyspnea inpatients with an exacerbation of asthma.
The findings suggest that biased attentional responses to threat, among children, can exert a specific influence on the tendency to experience anxiety in the face of stress.
Substances that are expected to exert a specific mechanism (MoA4) were not determined in the group of industrial chemical confirming the initial subdivision of the dataset into chemicals and pesticides.
Being aware of the importance of adipose tissue endocrine function and the key role of adipocytokines, such as adiponectin, in obesity and metabolic syndrome drives the necessity to develop new drugs that can exert a specific action on adipose tissue and on adiponectin levels.
Our results also imply that the indoor air environment exerts a specific selective influence on microbes, so as to enrich certain organisms in the air.
These observations suggest that myeloid-derived lymphatic endothelial cells may exert a specific functional role, which may explain the need of only a low number of these cells for the complete process of lymphangiogenesis.
It should be noted that the level of nucleolin in the nucleus remains constant in cells treated with actinomycin D, cycloheximide or tunicamycin that cause a marked reduction of surface nucleolin, thus indicating that these inhibitors exert a specific effect on the expression of surface nucleolin (Fig. 1C).
Polyanions exert a specific action on asbestos, particularly chrysotile, whereas silica is inactivated by nonionic polymers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com