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These results show for the first time that inhibition of the PDE7 enzyme leads to dopaminergic neuronal protection and therefore its inhibitors may exert useful therapeutic actions in patients with PD, a hypothesis that is amenable to clinical testing.
Additionally, HES may exert useful effects on the microvascular coagulation cascade of these patients by elevating levels of protein C and protein S [ 23].
The poor bioavailability of quercetin in the phase I clinical evaluation (Ferry et al, 1996) led to the conclusion that administration of quercetin may fail to furnish levels of bioactive species sufficient to exert useful pharmacological activity.
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In agreement with these considerations, compounds targeting tryptase functions, although designed as antiallergic drugs, could exert a useful antitumor activity as well.
These findings suggest that chrysin exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of NF-κB activation.
These findings suggest that GA exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of p65-NF-κB and IL-6/p-STAT3Y705 activation.
In return, the useful parents exert considerable power over their children long after they cease to be children.
But we also wonder how Britain can be truly useful to us, and to the west in general, if it chooses to stand apart in Europe rather than exert its proper weight in crucial matters.
Some of these CRISPR-Cas complexes can be deployed as genome engineering platforms, and anti-CRISPRs could therefore be useful in exerting spatial, temporal, or conditional control over genome editing and related applications.
Feedback is energy diverted from doing useful work to exert control over the putative machine operator, such as a passenger in a self-service elevator.
Therapeutic approaches aiming at a wider platelet inhibitory action than that exerted by aspirin may prove useful in patients with type 2 diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com