MAb C7 is the first Ab able to exert three different antifungal activities against C. albicans, such as inhibition of germination and adhesion and a direct fungicidal effect which extended to C. lusitaniae, Cryptococcus neoformans, Aspergillus fumigatus, and Scedosporium prolificans, suggesting a pleiotropic mode of action [11].
During development, Numb exerts two different roles that may seem opposite, as it maintains progenitor fate and promotes cell differentiation.
GntR5 has been identified as HutC, a transcriptional regulator that exerts two different roles, as it acts as a co-activator of transcription of the virB operon, and represses the hut genes implicated in the histidine utilization pathway [ 34].
For a direct comparison of the transcriptional responses exerted by the two different insects in this study, and to examine causal influences of the phytohormones JA, ethylene and SA, we conducted a path analysis.
Corticotropin-releasing factor (CRF) and the CRF-like peptide urocortin I (UcnI) exert their activity through two different CRF receptors, CRF1 and CRF2.
54 56 Fatty acids exert their effects in two different ways.
Sequence variation of CBF and COR genes could exert an effect at two different levels: either in the expression of the CBF genes themselves, via polymorphism in the respective promoter and/or in the expression of their downstream genes.
NTs exert their effects via two different types of cellular receptors: pan-neurotrophin receptor p75 (p75NTR) which binds all NTs with a similar affinity, and the family of high affinity tyrosine kinase receptors (Trk).
These molecules are associated with a more aggressive clinical behaviour in human lymphoma, and they appear to exert their influence through two different mechanisms: MMP-9 causes ECM degradation, whereas TIMP-1 shows an anti-apoptotic action [ 30, 31].
