Your English writing platform
Discover LudwigSuggestions(1)
Exact(5)
There were problems with the questionnaire adopted from the EXERT trial [ 23] with persistent, mostly random, errors occurring in the data despite retraining of research assistants.
Discussions with the EXERT trial team established that a simpler questionnaire would have been preferable for both trial participants and the analysis team.
Furthermore, some elements did not look reliable in the EXERT trial and not all of the data collected was used in the final analysis (Julia Critchley and Tony Isaacs, personal communications).
For instance, the EXERT trial, which evaluated GP referral for different exercise programmes, report randomising 949 out of 1105 people who contacted the team, but did not record the number of patients who were advised by their GPs to take part in the programmes, but did not wish to do so [ 23].
Assuming the intervention arm reaches 89 minutes of moderate intensity physical activity/week, and the control arm 55 minutes (SD = 70 mins), for 90% power at a 5% significance level, a sample size of 90 patients in each arm is required (in absence of good COPD data, EXERT trial data used) [ 55].
Similar(55)
Secondary outcome measures for the main study are reported in detail elsewhere [ 21] but include self-reported physical activity using the SPAQ [ 22] and Exercise Evaluation Randomised Trial (EXERT) questionnaire [ 23].
The inhibition-dominant LCA simultaneously explains (a) why accuracy levels off at non-ceiling levels as stimulus processing time increases, and (b) why information coming early in a trial exerts more influence on decision outcomes than information coming later [22], [23].
To determine if any single trial exerted an undue influence on the overall results, sensitivity analyses were preformed, in which each individual trial was removed from the meta-analysis, and the effect size recalculated with the remaining trials.
Intriguingly, the B > A pattern suggests that greater preparatory effort is exerted in nontarget trials than in target trials: In nontarget trials the cue may have higher utility, since the dominant target response bias must be overcome (i.e., target responses were required on 70% of all trials, and on 87.5% of the A-cue trials, but on 0% of B-cue trials).
The issue of radiological progression can be regarded an example for the influence clinical trials may exert.
This study urges to exert cautiousness in future trials of Sulfasalazine for the treatment of malignant gliomas.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com