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Several antiepileptic drugs exert their activities by inhibiting Na+ currents.
BMP ligands exert their activities by way of serine-threonine kinase receptors.
nTregs also use cell-cell contact mechanisms to exert their activities.
We asked whether glucocorticoids could exert their activities by interfering with the expression of CNP or its downstream signaling components.
It is reported that interferons exert their activities mainly by binding to specific membrane receptors on the cell surface.
Tregs may also exert their activities by lysing effector cells through the secretion of granzymes A and B and perforin.
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These molecules, which are anti-neoplastic drugs, exert their activity through activation of the spindle assembly checkpoint, thereby arresting cells in mitosis.
Polyphenols exert their activity through several mechanisms: carcinogen detoxification, DNA repair, cell cycle progression, activation of differentiation, and epigenetic modulation.
Corticotropin-releasing factor (CRF) and the CRF-like peptide urocortin I (UcnI) exert their activity through two different CRF receptors, CRF1 and CRF2.
Compared to resveratrol, analogues with ortho-methoxy substituents were found to be more potent inducers of QR and to exert their activity in a qualitatively different manner.
Generally, the IFNs are known to have wide ranging protective immunomodulatory, antiproliferative and antiviral effects, and exert their activity through multiple pathways.
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