Sentence examples for exert suppression from inspiring English sources

Monocytic MDSC express CD14 and exert suppression via arginase, iNOS and suppressive cytokines [ 29].

Because secretion of IL-10 and TGF-β is one mechanism through which T regulatory cells exert suppression of effector immune response, whether this cell population could be expanded in the spleen of vaccinated mice has been investigated.

In addition, Tregs require close contact with target cells to exert suppression [ 40].

In general, Tregs require close contact with target cells to exert suppression (Shevach, 2009).

Naturally occurring CD4+CD25+ regulatory T cells are not suppressive and require T-cell receptor interaction with a specific antigen or polyclonal stimulus to exert suppression.

These cells are characterised by high expression of CD52 and exert suppression by releasing soluble CD52, which ligates inhibitory Siglec receptors.

While in some differentiation programs p53 facilitates the process, in others it exerts suppression.

The specific mechanism by which the Treg exerted suppression of polyfunctional responses of CD8+ T cells remains to be determined.

However, once activated, Treg cells are capable of targeting other cells in the vicinity and exerting suppression in an antigen non-specific manner (Thornton and Shevach, 2000; Karim et al., 2005).

A reasonable hypothesis for the phenotype of the vt29 mutant (and to a lesser degree vt25 ), and one that now can be targeted in future studies, is that the vt29 gene normally exerts suppression of DA neuron excitability and/or DA vesicular release.

We also found that both NORE1A and NORE1B exert growth suppression effect via inhibition of cellular growth and colony formation of tumor cells and enhancement of cellular response to apoptotic stress.