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It shows that WC nanoparticles caused low transcriptional responses while WC-Co nanoparticles are able to exert responses similar to that of free cobalt ions, particularly the induction of hypoxia-like effects via interactions with HIF1α in human keratinocytes.
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Regardless of absolute values of K i and MRgluc, it is important to note that dietary changes as well as insulin administrations exerted responses in mice that are comparable to those in humans.
ABC transporters comprise various efflux proteins, some of which exert abnormal responses to exogenous compounds due to the presence of polymorphs.
Upon platelet activation, platelet-derived growth factors (PDGFs) are released locally where they exert various responses through local cellular and cytokine signaling pathways necessary for cell proliferation and remodeling at the cellular level (Everts et al. 2006).
Here we present an overview of the biochemical and structural research on riboswitches with a major focus on common principles and individual characteristics adopted by these regulatory RNA elements during evolution to specifically target small molecules and exert genetic responses.
Different levels of GSK3β inhibition are proposed to exert different responses depending on cell context or cell type [14], [56].
There are several distinctive features of TLR4 signaling that may explain why ultra pure LPS does not exert EC responses as do TLR2 and TLR5.
Our hypothesis was that tryptamine can exert vascular responses in the rat mesentery through 5-HT receptors and TAARs.
We also compared tryptamine with tyramine and β-PEA, which had failed to exert vascular responses in unconstricted preparations.
PARP inhibition is a tractable pharmacological target in vivo, as antagonists of other PARP homologs exert antineoplastic responses in breast and ovarian cancer [ 27, 28], as reviewed, [ 29].
However, at sites of vascular inflammation endothelial cells may exert adaptive responses against cell damage and denudation that promote plaque erosion and thrombosis in vivo.
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