Sentence examples for exert repression from inspiring English sources

miRNAs mostly exert repression of gene expression by blocking target mRNA translation and/or through mRNA decay as part of the miRNA-induced-silencing complex (miRISC), which includes GW182 and argonaute proteins (Ding and Han, 2007; Fabian and Sonenberg, 2012).

In such molecular machinery, HDAC activity plays an important role in exerting repression via its interaction, either directly or indirectly, with DNA-binding transcription factors (de Ruijter et al., 2003; Yang and Seto, 2007).

To keep Oct4 and Nanog expression within steady-state levels, these three genes interact so that (i) expression of Nanog activates FOXD3 and Oct4 but not above steady-state levels due to Oct4 exerted repression; and (ii) FOXD3 and Nanog activate Oct4 expression but not above steady-state levels due to Oct4 self-repression.

However, flamenco and COM exert their repression in somatic follicle cells, the starting points of the transposition events of these retrotransposons [63] [68].

This UTR contains two binding sites for miR-2, which exert strong repression in the developing larval eye (Lai and Posakony 1997).

It is well known that the presence of glucose exerts catabolite repression, preventing the uptake and utilization of lactose, whilst glycerol does not interfere with lactose induction or the ability to metabolize this sugar for energy.

The metabolism of glucose exerts catabolic repression.

Indeed, a large fraction of nonconserved sites exerted specific repression as efficiently as conserved sites when placed in reporters.

In t(8 14 q24 q11), the MYC proto-oncogene, which is also a target of NOTCH1 activation and maps at 8q24, is activated and fused to TCRA/D genes, exerting transcriptional repression of cell cycle inhibitors p27 and p21.

47– 49 It exerts gene repression both directly, via a histone methyltransferase domain (PR domain), and indirectly, via five zinc-finger domains that bind to the DNA and recruit histone deacetylases (HDACs) of the Groucho family.

Of note, whereas Sp1 sites are involved in positive regulation of both the LAMB3 and LAMC2 promoters, the LAMA3 promoter with a downstream Sp1 site mutated displayed strongly increased activity suggesting that in the LAMA3 promoter the Sp1 site exerts transcriptional repression (data not shown).