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D-Cycloserine may not always exert optimal efficacy, as there is evidence that, for example in social anxiety patients, the achieved fear inhibition may not be sustained [ 14].
Theoretically, it is conceivable that angiogenesis inhibitors will exert optimal activity in a situation of minimal residual disease with high-angiogenic potency such as could be the case in the adjuvant setting.
This entails answering some basic questions in rodents and primates, e.g., which levels of extracellular brain insulin (as opposed to CSF insulin) are actually achieved by intranasal insulin doses that exert optimal effects on cognition?
On the one hand, aspirin and curcumin seem to exert optimal adenoma-retarding activity at different stages of the lifetime of Apc Min /+ mice, aspirin early and curcumin late; on the other hand, we failed to observe additivity or synergy when both agents were administered sequentially.
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These two compounds also exerted optimal antagonistic activity against AR in reporter assays.
Compound 1f also exerted optimal antagonistic activity against ER in reporter and cell proliferation assays.
An initial population obtained by using uniform design exerts optimal performance of the proposed hybrid algorithm.
Superimposing the optimal activity conditions of cv-lysozyme 3 with those of cv-lysozyme 1 [ 57] and cv-lysozyme 2 [ 58] indicated that cv-lysozyme 3 exerted optimal lysozyme activity under the pH and ionic strength conditions that differ from that optimal for the other two lysozymes.
The relatively high protein binding and low volume of distribution of daptomycin recorded in humans or animal models represent a difficult challenge for defining a dosing schedule exerting optimal bactericidal activity against major categories of serious S. aureus infections [ 12, 21- 29] in various deep-seated compartments though minimizing skeletal muscle side-effects [ 30, 31].
Clinical and experimental evidence has shown that agents that exert an optimal endotamponade are very effective anatomically but are not biocompatible.
Ultimately, control could not be exerted in optimal fashion; that is, protection from negative consequences was seriously compromised when one's HIV-positive status was unintentionally disclosed.
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