The properly planned and conducted experiment was shown to determine optimum conditions for conducting the process in cases when models describing the tested properties exhibit no extremum while variables of conducting the process exert opposite effects on the studied properties.
Therefore, Ang II may exert opposite effects on passive avoidance memory according to its interference with brain mechanisms leading to the storage or retrieval of this aversively motivated task.
Since these markers are known to exert opposite effects upon binding to Tie-2, the similar beneficial prognostic effect remains to be elucidated.
This suggests that ONOO− might exert opposite effects on AMPK activity, i.e., AMPK activation via upstream enzymes and AMPK suppression via an unknown posttranslational modification by ONOO−.
Second, proteins in the same complex or pathway may exert opposite effects on a phenotype, playing as actors or repressors [18].
Genetic analysis of C. elegans has demonstrated that distinct serotonergic neurons regulate specific aspects of behavior [43] and that multiple 5-HT receptors may exert opposite effects on the same behavior [44].
We show that proteasome inhibitors and IM exert opposite effects on β-catenin: BOR and PSI inhibit its degradation and activate its CRT activity, while IM causes its inactivation (Figure 8A and B).
As an example, these magnitudes are shown in Table 2 for all coevolving pairs with a score >5 σ in the ZRes matrix of Figure 3. Less than 20% of these pairs (rows in bold in Table 2) have values of |ΔΔGi−ΔΔGj|> ΔΔGi+ΔΔGj), and thus identify positions that, on average, exert opposite effects on the stability of KDO8PS.
As summarized most clearly in Figure 7, in different GPCR systems ligand-induced receptor dimerization can exert opposite effects on the level of receptor enrichment in lipid rafts, depending in large part on the regime (monomer, oligomer and dimer) of unligated receptors.
