Some combination approaches have achieved enhanced antitumor effects in animal models and human clinical studies, 29, 30, 31 in which monotherapy has exerted only modest effects.
Therefore, it is maybe not surprising that exendin-4 exerted only modest effects on post-MI cardiomyocyte remodelling, which may have occurred directly or secondary to more pronounced effects on the ECM.
Whilst hypoxia exerted only modest effects on the production of mature miRNAs, we did see a significant influence of hypoxia on the operation of an exogenously introduced precursor miRNA.
Common variants, yet unidentified, exert only small effects on risk.
In the case of sample recovery, this component has been demonstrated to exert only a modest effect [ 16, 27], which was confirmed in the present study using spiked healthy volunteer blood samples.
Because lopinavir/ritonavir and nevirapine are used in both strategies (as either first-line or second-line ART), variations in drug costs exert only a modest impact on the economically preferred strategy (panels B and C).
Furthermore, whereas the normalization of a single metabolic parameter, such as vitamin D3, may exert only a modest effect on pathogenesis, the optimization of a comprehensive set of parameters, which together form a functional network, may have a much more significant effect on pathogenesis and thus on function.
Nuclear magnetic resonance measurements indicate that lipidation exerts only a modest and local effect on the Cav3 structure, with little impact on the structures of the N-terminal domain, the scaffolding domain, and the extreme C-terminus.
While 3′-methoxy-GTP exerted only a modest stimulatory effect (2-fold) on the rate of the reaction, no stimulation was observed with either 3′-dGTP or 2′3′-ddGTP.
