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Our preliminary experiments conducted with an intraperitoneal injection of rotenone, emulsified in oil, turned out to exert noxious effects; the rats presented liver necrosis and large weight loss (unpublished data).
Another mechanism, by which AGEs may exert noxious effects, is represented by their action on specific receptors (RAGE), which have been identified on the membrane of chondrocytes, tenocytes and fibroblasts [ 45, 46].
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Thus, there is circumstantial evidence to suggest that the wild-type SOD1 has the potential to exert ALS-causing noxious effects similar to those of mutant SOD1s.
On the contrary, consumption of a SAFA-rich meal exerts a noxious effect on endothelial function that starts at 2 h and is maintained up to 6 h postprandially.
Chemotherapy drugs used to treat cancer can be neurotoxic by either exerting a direct noxious effect on the brain or the peripheral nerves.
The ACC contains high concentrations of glucocorticoid receptors (GR) in laminas II, III, and V [6], is vulnerable to the noxious effects of glucocorticoids [7], [8], and may exert inhibitory control over the HPA axis via GR-mediated negative-feedback [6], [9].
It seems probable that if a product exerts no effect on the rat pancreas, the human pancreas will also be spared from noxious effects.
The damage isn't confined by geography; heroin and its noxious effects are overwhelming the US.
Introduction: Noxious effects of hyperoxia have been described for more than 60 years.
This suggests that reduced lung distensibility predisposes to the noxious effects of high volume ventilation.
However, further reduction seems necessary to avoid noxious effects on ecosystems.
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