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In conclusion, our results collectively demonstrate that androgens exert no direct effects on endothelial progenitor cell biology in vitro and in vivo.
In the present study, we have shown that androgens (testosterone and its active metabolite DHT) exert no direct effect on late EPCs in vitro and in vivo, as shown using standardized assays, including colony formation, adhesion and response to androgen replacement in vivo.
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This view that early experience and maternal care exert converging influences on offspring development stands in contrast to an alternative view that neonatal stimulation exerts no direct effects on pups but, rather, that maternal care solely mediates the effects of neonatal stimulation on adult functional outcome.
The ATD manipulation in itself exerted no direct effect on conflict adaptation.
However, EPO alone supports very little MEG growth 27 as maturing MEGs lose the EPO receptor 28, and EPO exerts no direct action on the TPO receptor c‐mpl 26.
19 Given that the tranilast concentration in tumor tissues in our mouse models was lower than 50 μM after repeated tranilast treatment (data not shown), it is considered that administration of tranilast into the tumor exerts no direct inhibitory effect on tumor cells.
As there is a higher level of the xprG transcript in the imeBΔ mutant, and XprG is a negative regulator of ndtA expression, we might expect to see a decrease in ndtA expression in an imeBΔ mutant rather than an increase if ImeB exerts no direct control over ndtA expression (i.e., acts only through XprG).
They were now unable to exert any direct influence through speeches at public rallies.
Collectively, these results suggest that the effects of DKK1 and DKK2 on B16F10 melanoma growth are mainly exerted through regulating angiogenesis with no direct action on tumor cell proliferation.
Secondly, endothelial dysfunction contributes to cardiac fibrosis via the reduced bioavailability of NO, known to exert direct anti-fibrotic effects involving the cyclic guanosine monophosphate (cGMP) pathway [ 41, 42].
The shutdown will most likely exert a direct drag on the economy in the fourth quarter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com