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As a full senescence response is not required to initiate this reaction program and acute stress-associated phenotype (ASAP) can appear prior to cellular senescence (Gilbert and Hemann, 2010), a more appropriate term for the chronic response that exerts long term effects after cell exposure to genotoxicity is a "DNA damage secretory program (DDSP)" (Sun et al., 2012).
We do not deny that increased family size can exert long-term influence on aspects of culture and social control.
The latter could be problematic in that persistent microglia activation can exert long-term deleterious effects on neurons and behavior.
A small minority of HIV-infected individuals, known as HIV controllers, is able to exert long-term control over HIV replication in the absence of treatment.
There is evidence that melatonin and its metabolites could bind to nuclear sites in neurones, suggesting that this hormone is able to exert long-term functional effects in the central nervous system via genomic mechanisms.
This study was designed to investigate (i) whether systemically administered melatonin can exert long-term effects on spinal cord windup activity, and (ii) whether blockade of melatonin degradation with eserine could prevent this effect.
Epigenetic alterations can be mitotically inherited in somatic cells and can exert long-term effect on gene expression.
Since then, several animal studies have supported the concept that maternal malnutrition during pregnancy may exert long-term changes in the offspring [5], [6].
Maternal nutrients affecting one-carbon metabolism during gestation can exert long-term effects on the health of the progeny.
Physical activity can also exert long-term effects on improvement in insulin sensitivity through increased fat-free mass (10).
A key question to be resolved is, how does early exposure to breast milk-derived SIgA exert long-term effects on host-microbial mutualism?
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