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Our study demonstrated that the CBD targeted PDGF to the collagen scaffold to exert its functions, and it suggested this could be an effective system for targeting tissue regeneration and wound repair.
Many reports indicate that the inhibition of GSK-3β reduces ischemia/reperfusion cardiac injury through the regulation of the mPTP opening, indicating that it could exert its functions by modulating mitochondrial activity [29] [32].
It is therefore possible that, given the strikingly similar domain organization, mammalian ortholog of the cytoplasmic PNGase, besides its PNGase activity, may also exert its functions through the similar deglycosylation-independent mechanism, and indeed it was suggested by our observation that the defect of Pngl mutation was rescued by the expression of Ngly1, a mouse ortholog of Pngl (Table 2).
In the case of p53, it needs to interact with several other proteins to exert its functions, which contribute to p53's conformation and affinity for its target DNA.
Ghrelin needs the enzyme GOAT to be acylated, a step essential for binding to the GHSR1a receptor to exert its functions.
Once activated, Akt can phosphorylate many substrates to exert its functions.
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Therefore, Vpr is present during early stages of infection and available to rapidly exert its function on the cells it first encounters, DC of the mucosal membranes.
Thus, Sgs1 might need a structurally proficient MRX complex in order to exert its function in resection.
Cut might exert its function through transcriptional regulation of a gene product involved in regulating the degradation of Arm.
These findings suggest that Rho3 may also exert its function partly through its target protein(s) involved in Golgi/endosome regulation.
We speculate that NleL may exploit the free ubiquitin pools in the host cell to exert its function without the canonical substrates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com