A biological system's robustness to mutations and its evolution are influenced by the structure of its viable space, the region of its space of biochemical parameters where it can exert its function.
Therefore, Vpr is present during early stages of infection and available to rapidly exert its function on the cells it first encounters, DC of the mucosal membranes.
As BOK is highly expressed in reproductive organs and granulosa cells, it is not surprising that BOK may only exert its function in limited cell types and/or under particular stress conditions.
Following ionizing radiation-induced DNA damage, cell-cycle arrest in the G1- or G2-phase of the cell-cycle prevents or delays DNA replication or mitosis, providing time for the DNA repair machinery to exert its function.
Interestingly, amplification and not just expression of MYCN has a strong prognostic value, although this fact appears quite surprising as MYCN is a transcription factor that requires dimerising with its partner MAX, to exert its function.
By considering the existing irreversible losses in the hybrid system, the operating current density region of the PEMFC permits the absorption refrigerator to exert its function is determined and the analytical expressions for the equivalent power output and efficiency of the hybrid system under different operating conditions are specified.
Thus, Sgs1 might need a structurally proficient MRX complex in order to exert its function in resection.
Cut might exert its function through transcriptional regulation of a gene product involved in regulating the degradation of Arm.
We speculate that NleL may exploit the free ubiquitin pools in the host cell to exert its function without the canonical substrates.
Our laboratory has developed a protein delivery protocol that allows the uptake of exogenous protein that can exert its function in multiple cells including podocytes.
Cut might exert its function either by blocking the Wg signaling pathway or, alternatively, by inhibiting the expression of every Wg target gene.
