Sentence examples for exert its activity from inspiring English sources

Semagacestat is generally referred to as a γ-secretase inhibitor, but we note that it increases levels of amyloid-β peptide 42 (Aβ42) in the blood at low concentrations, suggesting that it may exert its activity at an allosteric site rather than the active site of the enzyme.

It is possible that domain 5 does not exert its activity by interacting with muNS domains and/or it is not properly folded when expressed alone.

These results could be explained by GS being unable to exert its activity under the assay conditions because it is trapped in the LBs.

Thus, it is expected that Trastuzumab-Probiomed can exert its activity through the reported mechanisms of action, including HER2 downregulation, prevention of the heterodimer formation, initiation of Gl arrest, induction of p27, and prevention of HER2 cleavage [ 37].

It also seems that any process that requires the mind "to exert its activity, and put forth its strength, in order to surmount any difficulty," is naturally pleasurable, as is the mind's consciousness of its success in surmounting any difficulty (Gerard 1759, 3).

Interestingly, we detected a reduction in the dopamine-induced conformational change in aSyn, suggesting that dopamine must gain entry into the cells in order to exert its activity on aSyn (Fig. 5A D).

11 In the 1990s, rapamycin was found to exert its activities by an evolutionarily conserved pathway that integrates signals from growth factors, nutrients, and energy status.

It exerts its activity through high affinity interaction with an intracellular receptor protein, the immunophilin FKBP12.

Preliminary studies of the mechanism of action revealed that the most active compound exerts its activity through ERK1/2 signaling pathway activation, especially on DA neurons.

It probably exerts its activity via DNA topoisomerase II (topo II) inhibition.

We also provide evidence that SM83 exerts its activity by inducing inflammation and immune cell activation, resulting in immunogenic death of cancer cells.