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We also found that cancer cells over-expressing RASSF1C exhibited increased phosphorylation of ERK1/2 compared to control cells (but no increase in total ERK1/2 levels), suggesting that RASSF1C may exert its activities in part through the activation of the ERK1/2 pathway.
11 In the 1990s, rapamycin was found to exert its activities by an evolutionarily conserved pathway that integrates signals from growth factors, nutrients, and energy status.
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It is possible that domain 5 does not exert its activity by interacting with muNS domains and/or it is not properly folded when expressed alone.
These results could be explained by GS being unable to exert its activity under the assay conditions because it is trapped in the LBs.
Leptin may exert its activity not only through ObR, but also through crosstalks with other signaling systems.
A MFC derived from two or more different pharmacophores exerts its activities by interacting with respective receptors of its constituent pharmacophores.
The small-size TYLCV exerts its activities mostly by recruiting host factors through protein-protein and protein-DNA interactions [ 25– 31].
This apparent conflict in the data may be because this compound exerts its activities via different pathways in different types of cancer cells [ 7].
Albeit present, IFN-γ is not capable of fully exerting its activities probably due to the presence of counter regulatory products such as IL-10 [ 14, 15].
It exerts its activity through high affinity interaction with an intracellular receptor protein, the immunophilin FKBP12.
Preliminary studies of the mechanism of action revealed that the most active compound exerts its activity through ERK1/2 signaling pathway activation, especially on DA neurons.
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