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In different trials, it has been reported to exert improvement in OA [ 18], have a moderate effect [ 19] or show no difference with a placebo [ 20, 21].
However, the difficulty of building control group for the cases with subepithelial infiltrates who do not exert improvement in symptoms and findings after 3-month treatment with corticosteroids should be taken into consideration.
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Pre-treatment with kefir milk exert significant improvement in all the tested parameters.
Interestingly, PEG with higher molecular weight (4 kDa) failed to exert significant improvement in neuronal injured mitochondria indicating that PEG-mediated mitochondrial protection is dependent on the size of PEG [ 14].
In comparison with benazepril, ATRA exerted no improvement in hypoproteinemia, but more significant decrease in serum Cr level in GS rats.
On the contrary, D-chiroIns alone is unable to exert significant improvements in the ovarian cell functions, as its beneficial effects are mainly limited to the non-ovarian tissue in which it may significantly inhibit the negative cellular consequences of hyperinsulinemia.
In addition, healthy children may exert a small improvement in peak VO2 by increasing physical activity (ceiling effect) [ 33, 34].
Moreover, the treatment of patients with AD with certain nutraceutical formulations containing NAC exerts a significant cognitive improvement in comparison with placebo.
Crumb Tire Rubber (CTR) modification of bitumen has been extensively proven that exerts a notable improvement the in-service properties.
Physical activity can also exert long-term effects on improvement in insulin sensitivity through increased fat-free mass (10).
Bevacizumab (BVZ; Avastin, Roche, Basle, Switzerland), an anti-VEGF humanised monoclonal antibody, has been shown to exert objective tumour responses and improvement in median time to progression (TTP) in advanced carcinoid tumours (Yao et al. 2008).
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