Sentence examples for exert downstream from inspiring English sources

The low nuclear permeation of ERK1 suggests that during steady stimulation and translocation, a large fraction of nuclear ERK1 might be inactivated and is therefore unable to exert downstream effects.

The converging evidence from these studies on different cognitive modulations of pain (e.g. attention, hypnosis, anticipation, feeling of control) points to the importance of the anterior medial wall for pain modulation that seems to exert downstream control via subcortical areas such as the amygdala and periaqueductal grey.

However, several signaling pathways may converge on these molecules to exert downstream function.

Our studies are among the very first reports to show that epithelial cell-derived EVs exert downstream functions on alveolar macrophages.

Leptin binds to LepRb and activates JAK2 (Janus kinase 2)/signal(signal transducer and activator of transcription 3) signal cascade and exert downstream functions.

This phenomenon can be explained due to the fact that lauric acid, a medium chain fatty acid also present in LPS, can exert downstream signaling dependent on TLR4 in macrophages [ 90, 91].

How metformin-activated AMPK exerts downstream effects to confer healthspan benefit is not known.

It is conceivable, therefore, that anti-inflammatory actions exerted downstream of 25(OH D 52, 97 are reduced in patients.

Importantly, the action of nNOS and those of exogenous NO are exerted downstream of mitoKATP channels and upstream of p38 MAPK.

Rather, ablation of p38δ influences insulin secretion by a direct effect on the exocytotic machinery that is exerted downstream of [Ca2+]i elevation.

For example, if BRCA1 exerts downstream effects on transcription, expression, or circulating levels of members of the insulin-like growth factor system as suggested by recent work [ 39- 41], then breast tissue may be denser among BRCA1 mutation carriers [ 38] regardless of their level of protein intake.