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In this contribution, our observations demonstrate that different-sized ZnO nanoparticles exposed to SMMC-7721 cellsr could could exert dose-dependent cytotoxicity suppression in vitro, and this cytotoxicity of nanoparticles was time depended and dose depended, while the size-depended effect was not clear in the scope from 20 to 100 nm.
In a 12-week study in Japanese patients with T2D, treatment with vildagliptin was shown to exert dose-dependent glycaemic control and was well tolerated [ 16].
Therefore, 17β-oestradiol (E2) was found to inhibit cellular apoptosis, to increase antibody production by B cells and to exert dose-related effects on T-cell functions [ 7].
As2O3 also has been reported to exert dose-dependent dual effects on acute promyelocytic leukemia cells, inducing apoptosis at relatively high concentrations (0.5 2 μM) and inducing partial differentiation at low concentrations (0.1 0.5 μM) (Chen et al. 1997).
In in vitro studies LJ has exerted dose dependent inhibitory activity on α-amylase and pancreatic lipase.
HO-1 inhibitor exerted dose- and time-dependent cytostatic/cytotoxic effects as measured with crystal violet staining (Fig. 1).
Hence, it can be concluded that fish oil exerts dose and time dependent chemopreventive effect in experimentally induced colon cancer which may be mediated through an inhibition in lipid mediated signaling and aberrant Wnt signaling.
In previous studies, we have observed that ethanol and water extracts of I'm-Yunity™ (PSP) exerted dose- and time-dependent anti-proliferative effects in human promyelocytic HL-60 leukemic cells.
In this study, AgNPs in vitro conditions exerted dose-dependent cytotoxic effect on MCF-7.
In addition, compound 35 exerted dose-dependent anti-nociceptive effects in the formalin test.
Tests of various doses of PTZ showed that the drug exerts dose-dependent discriminative control over response.
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