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In our earlier studies, one of the halogenate salts, namely potassium bromate (KBrO3), being classified as a carcinogen, was shown in vitro (5 mM) and in vivo to exert damaging effect to membrane lipids in porcine thyroid [ 29].
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Over-expression of MCP-1 exerts various damaging effects via increased production of superoxide radicals from macrophages, release of lysosomal enzymes, cytokines, growth factors and cellular adhesion molecules [ 49, 50].
MEHP but not DEHP exerted a dose-dependent DNA damaging effect to B. subtilis in Rec-assay.
In the absence of DNA repair, DNA damaging agents exert greater effect.
The ability of Aloe vera to exert a significant and prevention on the oxidative damage caused by APAP overdose when given in mice confirms its anti-oxidative damage effect.
The traditional view has been that ROS exert toxic effects by damaging or killing cells under pathophysiological conditions.
Treatment of AS reduced these damages, but NM did not exert positive effect on these damages in diabetic rats.
These findings indicate that sdAbA1 exerts anti-inflammatory and anti-joint damage effects on RA by inhibiting MMP-9 expression and secretion of IL-6 and IL-8.
Many conventional cancer therapeutic agents exert their effect by causing DNA damage and thus retaining a functional G2 is believed to confer resistance to many such therapeutic agents.
The extract might also exert its effect by reducing the oxidative damage due to free radicals.
This strategy is based on inducing CNS-reactive T cells which home to areas of damage and exert beneficial effects locally in a process termed "protective autoimmunity" [1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com