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Since CK2 exert considerable effect on AKT activation by phosphorylation of Ser129 residue of AKT (Supplementary Figure S-4b, upper figure), the CK2 refractory mutant was prepared (non-responsive towards perturbation in the level of CK2 activity) viz.
Although individual phthalate exposures in humans are generally asserted to be below the no observed effect level (NOEL), combinations of man-made estrogenic chemicals, individually below NOEL concentrations, have been shown to exert considerable effect in a yeast reporter gene assay using the human estrogen receptor-α (Rajapakse et al. 2002).
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Disulfide bond formation is speculated to exert considerable effects on residues within the kinase domain, most notably within the active-site cleft.
Hence, KIEs may exert considerable effects over all variables of the system (metabolite concentrations, fluxes, and distribution of isotopes), and thus potentially jeopardize the biological value of ILEs.
Second, the patients with T2D in this study were receiving various anti-atherogenic drug interventions such as anti-hypertensive agents, statins and insulin therapy that can exert considerable effects on FMD of the brachial artery and related atherosclerotic risk factors.
The uptake of this high concentration of Br by vegetables is influenced not only by plant species and physicochemical characteristics of soil but also by temperature and rain fall which may exert considerable effects.
Second, sexually antagonistic alleles, though in the minority, may nonetheless exert considerable effects on net fitness because the genetic load associated with them tends to be greater than for concordantly selected alleles [ 38].
The spatial variability also exerted considerable effect on the leaf yield and stevioside content in leaves.
The dry-out limits of the heat pipe exerted considerable effects on the tank performance.
Magma density and mean residence time exert a considerable effect on crystal growth, nucleation, and agglomeration.
Uncertainty does exert a considerable effect.
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