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Granulocyte macrophage colony-stimulating factor (GMCSF) and MCP3 (aka CCL7) exert complementary, nonoverlapping, proimmune effects on responsive lymphoid and myeloid cells.
Therefore the membrane and cell wall actions of ranalexin may exert complementary effects in killing S. aureus MRSA-252.
In that sense, chaperones and IDPs may exert complementary functions and thereby control cellular homeostasis on multiple levels.
These exert complementary and concerted functions in a spatiotemporal relationship during the development of the neurons of the visceral nervous system (D'Autréaux et al., 2011).
Thus, Bcl-2 homologues exert complementary effects on cell survival, and their simultaneous inhibition is expected to promote efficient cancer cell death.
One problem with proteasome inhibitors is the emergence of resistance; however, the combination of several proteasome inhibitors that exert complementary specificities appears to overcome the problem of resistance and might have the added benefit of enabling reduced dosing of the individual drugs (Refs 28, 29).
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Whether adenosine exerts complementary cardioprotective effects to ACE inhibitors and beta-blockers could be the subject of further studies.
We found the existence of a generation gap in terms of interest in and knowledge regarding food education, which suggests that there is room for working together to exert a complementary role between generations.
44 In summary, sitagliptin and metformin exert a complementary glucose-lowering effect and represent a well tolerated option for patients requiring therapy for type 2 diabetes.
In such models, CRWN1 and CRWN2 would act to prevent chromocenter aggregation and CRWN4 would exert a complementary effect to maintain chromocenter integrity.
Although considerable evidence suggests that these agents exert multiple complementary actions that should directly and indirectly enhance β-cell health, it seems premature to definitively conclude that therapy with GLP-1R agonists is likely to be associated with sustained preservation or enhancement of β-cell function in subjects with type 2 diabetes.
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