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Importantly, the formed HMSs@Au-PEG-RGD NSs/DOX nanoplatform can specifically target cancer cells overexpressing αvβ3 intergrin and exert combination chemotherapy and PTT efficacy to the cells in vitro and a xenografted tumor model in vivo.
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The presented methodology is validated using a modified Arcan test of a single joint, which enables to exert a combination of shear and pull-out loads.
It is also important to point out that we are certainly exposed to a mixture of EDCs, and the cumulative effects that these chemicals may exert in combination are only now being studied (Kortenkamp 2008).
However, the effect of some genetic variants is only exerted in combination with environmental or other genetic risk factors [38].
The results of the gene expression levels indicate that the coencapsulation of resveratrol and 5-FU in liposomes exerts different combination effects on different genes.
Here, we show that some newly synthesized compounds may exert such a combination of functions.
Furthermore, miRs exert control in combination with other regulatory elements such as transcription factors [8].
It was important to demonstrate that the individual drugs within the 267/Dt combination exert benefits consistent with their individual mechanisms of action.
Furthermore, we show that these agents, alone or in combination, exert their effect on cell growth via retinoid receptor-independent mechanisms.
Disease mutations in RPGR 1– 19, RPGR ORF15, or RID of RPGRIP1α 1, singly or in combination, exert distinct effects on the subcellular targeting, co-localization or tethering of RPGRIP1α1 with RPGR1 19 or RPGRORF15 in kidney, photoreceptor and hepatocyte cell lines.
We report that these compounds in combination exert a variable antiproliferative effect across multiple breast cell lines, which is synergistic in SK-BR-3 cells and triggers cell signaling events not predicted by the activity of either compound alone.
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