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These compounds share common features and determinants needed to exert an efficient GPx-like activity, such as polarizing groups in close proximity to selenium and steric effects.
Spleen cells from animals treated with combination therapy transferred to diseased animals failed to exert an efficient control of the disease process (Figure 5-B) as measured using percent of clinical amelioration.
The present results confirmed that GSH is able to exert an efficient protection mainly toward 14CHCl3 oxidation intermediates.
The dihydropyridine calcium channel blocker (CCB) is one of the first-line antihypertensive drugs for most patients with hypertension and is known to exert an efficient BP lowering effect and a strong inhibitory effect on cardiovascular events [ 3, 4].
Therefore, muscle cells exert an efficient HSF1-mediated heat shock response to prevent denaturation of the reporter protein.
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BSO stimulated the PKCδ enzymatic activity of SK-N-BE-2C cells 3-fold, whereas DPI pre-treatment exerted an efficient preventive effect (Figure 1B).
Although the effect of FCCP on TPA-induced decrease in mitochondrial membrane potential was unable to be detected because of the extensive dissipating effect of FCCP alone (Fig. 4C), our current data still indicates that mitochondrial uncoupling exerts an efficient inhibiting effect on p53-associated mitochondrial dysfunction.
Since GSH exerts an efficient buffering role against ROS (Bindoli et al., 2008; Mieyal et al., 2008), a deficiency of GSH puts the cell at risk for oxidative damage from ROS and related reactive species.
Collectively these data indicate that Trx80 activation of monocytes enhances their bactericidal activities and exerts an efficient control of the infection by intracellular bacteria, independently on the site of replication.
Reinstatement of p53 in vivo exerts an efficient suppression of different types of established tumors, supporting the idea of pharmacological restoration of p53 to combat cancer.
The combines also exert an influence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com