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It also promotes migration of antigen-specific T cells from the draining lymph node to the site of M. tuberculosis infection where they exert adaptive control of M. tuberculosis through granuloma formation [38].
Pathogen pressure can exert adaptive changes in host genes that are crucial components of the vector's defence.
However, at sites of vascular inflammation endothelial cells may exert adaptive responses against cell damage and denudation that promote plaque erosion and thrombosis in vivo.
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By significantly up-regulating catalase levels over the entire range of doses from 0.5 to 4 Gy, the inhibitor of Hsp90 exerted adaptive protection and modified the early radiation response of the human blood cells.
Thus, in response to an increased substrate supply, the liver exerts several adaptive physiological responses to prevent cytotoxic accumulation of lipid species.
This method exerts self-adaptive control over local update rates of solution by predicting and correcting changes to simulation variables in accordance with local physical scales.
Dramatic evolutionary modifications of functional V gene germline repertoires are assumed to reflect selective pressures exerted on the adaptive immune system and in turn result in beneficial changes in the expressed TR repertoires.
The selection pressure exerted by the adaptive immune response rapidly selects for escape variants, leading to persistence of HCV strains that are unrecognisable by circulating T cells and antibodies in both natural infection of humans and in animal infection models [36,102-104].
Moreover, by the secretion of different cytokines and chemokines, NK cells can also stimulate inflammatory responses and exert a control on adaptive immune responses [ 1, 2].
It has been suggested that these periods of marine inundation exerted an influence on adaptive radiation (the proliferation of organic lineages) by greatly increasing the area of shallow seas where life was most abundant.
It is, however, possible that induction of the PD-L1/PD-1 pathway represents a mechanism of adaptive resistance exerted by tumors infiltrated by effector T cells, and is therefore a marker of an ongoing antitumor immune response.
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