Regulatory SNPs may exert a tissue-dependent effect on gene expression but in general, "allele specific expression differences between individuals dominate over tissue-specific effects" [ 60].
Taking these studies into account, we would assume that due to the complex nature of ischaemia-reperfusion injury and inflammation that occurs in animal models of HS, serum concentrations lower than 5 IU/ml would be inadequate to exert a tissue-protective effect.
Radionuclide therapy (or "targeted", "metabolic" or "molecular" radiotherapy) may be defined as a radiation therapy that uses local, loco-regional or generally administered open (i.e. "unsealed") radionuclides to achieve a transfer of radiation energy to a pathological target tissue and by this means to exert a destructive tissue effect.
Matricellular proteins are a set of structurally unrelated ECM proteins that do not exert a primary role in tissue architecture but have regulatory roles in embryonic development, tissue injury, inflammation and tumor progression.
Matricellular proteins are a set of non-structural extracellular matrix (ECM) proteins, mainly including thrombospondins (TSPs), OPN, tenascins, SPARC, POSTN and CCNs, which do not exert a primary role in tissue architecture but regulate similar biological functions in response to external stimuli during embryonic development, tissue injury, inflammation and tumor progression (Bornstein, 1995).
It is reasonable to suspect that smaller changes in some miRNAs may exert a greater influence in tissue behavior; i.e. if they modulate the expression of more important proteins.
However, recent data suggest that serum lipoproteins exert an influence on tissue insulin sensitivity both directly and through the activity of their major lipoproteins.
Morphologic and morphometric analyses of lungs show that the alveolar surface forces exert a moulding effect on alveolar tissue elements.
Since the micronutrients are taken up by the seeds during imbibition [14], this may indicate that only the micronutrient fraction already present in the plant tissue can exert a protective function after onset of the cold-stress period, while root uptake from the external medium is largely inhibited under these conditions.
Being aware of the importance of adipose tissue endocrine function and the key role of adipocytokines, such as adiponectin, in obesity and metabolic syndrome drives the necessity to develop new drugs that can exert a specific action on adipose tissue and on adiponectin levels.
It is unknown whether an increased perfusion pressure can exert a beneficial effect on gastric tissue perfusion.
