CONCLUSIONS: Our preliminary studies suggest that aspirin exerts a time-dependent effect on circulating EPCs.
Myelin exerts a time-dependent effect on expression of TNF-α, IL-1β and MIF.
All QTLs showed a time-dependent effect.
Trientine treatment exerted a modest time-dependent effect to ameliorate the effects of diabetes on body-weight (P = 0.035) whereas it had no measurable effect on blood glucose levels or heart rate.
In striatal slices, 3-HK exerted a concentration- and time-dependent effect on lipid peroxidation, inducing both pro-oxidant actions at low (5 20) micromolar concentrations, and antioxidant activity at a higher concentration (100 µM).
Phencyclidine (PCP) and dizocilpine (MK-801) exert time-dependent effects on the expression of immediate early genes in rat brain.
(C) Time-dependent effect of SLE on melanoma growth in a B16F10 allograft mouse model.
Overall, the above-mentioned gene expression studies showed that aripiprazole may exert complex dose- and time-dependent effects on multiple neurotransmitter systems beyond the aripiprazole receptor profile, as they also involve systems, such as the glutamatergic system, that are not directly targeted by the compound.
Notably, intestinal bacteria maintain homeostatic balance in mammals via multiple dynamic biochemical reactions to produce several metabolites from undigested food, and those metabolites exert various effects on mammalian cells in a time-dependent manner.
Indeed, it has been proposed that these discordant functions of Wnt5a may affect CRC prognosis in a time-dependent manner, whereby early Wnt5a expression exerts a favourable effect by inhibiting tumour growth through canonical Wnt suppression, whereby late expression of Wnt5a exerts a deleterious effect by promoting tumour invasion through non-canonical Wnt activation (Wang, 2009).
In the case of CaCO3/DOX, the drug is released in a time-dependent manner from the CaCO3 nanocrystals before exerting its effects on the cells.
