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These findings underscore that the metaboreflex may exert a robust vasoconstriction which may restrain coronary vasodilation.
The superior beneficial effects of cyclosporin A may indeed stem from its ability to inhibit MPT-driven RCD and simultaneously exert a robust anti-inflammatory activity.
Thirdly, the nuclease-resistant extracellular miRNAs were predominantly associated with RNA binding proteins such as argonaute proteins (Ago1 or Ago2), nucleophosmin (NPM1), or ribosomal proteins [ 64], which exert a robust protective effect on miRNAs from abundant nucleases in extracellular space.
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Furthermore, within 24 h, complete elimination of human iPSCs was achieved by culture in the presence of lectin-toxin fusion protein, indicating that rBC2LCN-PE23 exerts a robust cytotoxic effect on human iPSCs.
In contrast, PACAP at low concentrations exerted a robust protection against cell degeneration of NPCs induced by IFNγ, The enhanced cell viability induced by PACAP was accompanied by increases in p-Bad that can inhibit the mitochondrial mediated cell death [21].
Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos.
In our study, pretreatment with Go6976 (a classical PKC inhibitor) exerted a robust inhibitory effect on nSMase2 induction, whereas Bis pretreatment had a mild effect.
Strikingly, the drug combination exerted a robust synergistic effect on the expression of all three methylation steps of H3K4 in both adenocarcinoma cell lines (Fig. 4).
This study has shown that the combination of azilsartan medoxomil with amlodipine exerts a robust additional antihypertensive effect compared with placebo plus amlodipine.
Our results have demonstrated that lunasin in combination with IL-12 or IL-2 exerts a robust synergistic effect on increasing IFNγ and granzyme B expression by NK cells; and this synergism leads to strong NK activation with enhanced cytotoxicity.
The results clearly indicate differences in the effects of these two manipulations in terms of both directionality and magnitude, with reward motivation exerting a robust influence on proactive control, whereas positive emotion had much weaker effects.
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