In contrast, commercial polystyrene nanoparticles failed to exert mitochondrial effects.
Similar approaches could be used to study the effects of commercial nanoparticles, which, in addition to their chemical composition, may exert mitochondrial effects based on size, surface area, and surface charge.
The results indicate that salinomycin, when used above μM concentrations, exerts direct, mitochondrial effects, thus compromising cell survival.
67, 68 They may also exert a deleterious effect on mitochondrial function.
In this study, we have shown that increased copies of PGC-1α are sufficient to exert an effect on mitochondrial function through increase in mitochondrial membrane potential, and that PGC-1α is required for the stress-induced increase in mitochondrial membrane potential.
At the mitochondrial level, such neurotoxic actions affect the components of the OXPHOS by depletion of ATP levels (Ref. 64), and they exert a secondary effect on the mitochondrial ATPase.
In contrast to the particulate pollutants, artificial polystyrene microspheres (size < 100 nm) did not exert an effect on mitochondrial swelling, and the mitochondria remained fully responsive to Ala.
> -wrap-foot> OPA1 mutations exert a deleterious effect on in vivo mitochondrial function, irrespective of mutational subtypes and disease severity.
In plants, PHBs are involved in maintaining mitochondrial efficiency and exert a positive effect on plant development, cell proliferation and senescence (Ahn et al., 2006; Van Aken et al., 2007; Chen et al., 2005; Jiang et al., 2006).
Indeed resveratrol, a SIRT1 activator, was associated with upregulation of eNOS and induction of specific mitochondrial biogenesis factors, which exert a vasoprotective effect [ 139].
