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Stat3 can exert a large number of effects as a signaling regulator to a number of downstream endpoints.
PLA2s from snake venoms exert a large number of pharmacological activities [ 35, 54] due to a process of accelerated micro-evolution through which a high mutational rate in the coding regions of their genes has allowed the development of new functions, mainly associated with the exposed regions of the molecules [ 13].
PLA2s from snake venoms exert a large number of pharmacological activities due to a process of accelerated evolution through which a high mutational rate in the coding regions of their genes has allowed the development of new functions, mainly associated with the exposed regions of the molecules [ 29].
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Thyroid hormone exerts a large number of influences on the cardiovascular system.
VEGF is an angiogenic peptide that also exerts a large number of diverse neuronal effects in the central nervous system [ 36].
The endothelial monolayer lining the vascular sys-tem exerts a large number of different permeabilities depending on the specific function in the various organs and tissues (40, 41).
Thyroid hormone exerts a large number of influences on the cardiovascular system involving cardiac contractile effects, electrophysiological function, and cardiac structure [ 1– 3].
Cadmium exerts a large number of adverse effects on ecosystems and human and animal health [ 5, 6]; this metal is embryotoxic, causing different kinds of malformations and lethality in mammals [ 7, 8] as well as amphibians [ 1, 9– 14].
The process of metastasis relies on a series of stochastic and sequential steps, with selective pressure exerted on a large number of genetically volatile cancer cells to produce a very small fraction of tumor cells with the ability to navigate the transition from primary tumor cell to end-organ metastasis.
It has been shown to exert antimicrobial action against a large number of microorganisms including bacteria, yeasts, and mould.
Estrogens are essential for development of the reproductive system in women, in whom they exert beneficial effects in a large number of tissues, including breast, bone, brain, and cardiovascular system.
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