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Silicate bioactive glasses are thought to have a future in bone tissue engineering because they exert a genetic control regulation over the osteoblast cycle and rapid expression of genes.
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This suggests that common genetic polymorphisms at IL18 do not exert a significant genetic effect in the development of SLE.
Fung et al. (2006) claimed that there is no common genetic variant that exerts a large genetic risk for late-onset Parkinson's disease in white North Americans.
Multiple SNPs were associated with CHD-related quantitative traits, with some associations restricted to a single marker and others exerting a wider genetic 'footprint'footprint
Multiple sclerosis is a chronic inflammatory disease of the central nervous system in which complex genetic factors exert a profound influence on susceptibility.
For example, Emmerson et al. found that both urate clearance and the fractional excretion of uric acid were more similar in monozygotic twins than in dizygotic twins, which indicates that genetic factors exert a key control on the renal excretion of uric acid [ 16].
On the other hand, the genetic background may exert a relevant adjunctive role in the risk of disease development.
Genetic factors also exert a strong influence on the regulation of plasma lipids, with heritability estimates for fasting plasma lipids ranging from 35 to 60%[6 8]].
The DNMT1 genetic polymorphism may exert a modifying effect on the association between SAM and LINE-1 methylation status in men, especially when plasma SAM level is low.
We (Tycko) discussed published and unpublished data from our group showing that genetic haplotypes can exert a major influence on DNA methylation patterns.
Since genetic background can exert a profound effect in parameters such as metabolism and growth ratio, we measured IGF-I circulating levels in our own RasGrf1 −/− model.
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