Sentence examples for exert a functional from inspiring English sources
Syk has several interacting signaling partners e.g. Vav, the phophoinositide-specific phospholipase C PLCC) isozymes PLCγ-1 and PLCγ-2, and Cbl which are known to exert a functional impact on different leukocyte functions including cell migration [10] [17].
Another SNP in region 3 that ENCODE data suggests may exert a functional effect is rs2736108.
The SNP rs760477 is located within intron 4 and is unlikely itself to exert a functional effect, and no disease-associated polymorphisms were identified in the surrounding exons.
Ectopic overexpression of miR-146a in HEK293T exosomes was previously shown to exert a functional effect upon recipient cells, including downregulation of target gene expression [ 24].
Hence, it can be hypothesized that the dys-methylated and dys-regulated genes also exert a functional role in the heart.
This finding supports the current evidence that EDN3 may exert a functional role divergent to that of EDN1/EDN2 in the human mammary gland [ 18].
Whether or not loss of S100A10 in the tumour microenvironment exerts a functional role in follicular thyroid neoplasia is a subject of future investigations.
Interestingly, during liver fibrosis autophagy exerts a functional paradox, it has an antifibrogenic effect in hepatocytes or in macrophages while it has a pro-fibrogenic role in hepatic stellate cells.
Even when the arbitrary cut-off for significant expression differences was reduced to only 1.5 fold, the statistically significant association between up-regulation of SnoN in MSS CRCs and down-regulation in MSI-H CRCs was maintained (P ≤ 0.001), suggesting that even subtle changes in SnoN gene expression levels are capable of exerting a functional effect.
Multiple functions have been ascribed to FHL2, and it is puzzling how a protein that consists of LIM domains only and that lacks any obvious enzymatic activity can exert such a functional diversity.
These observations suggest that myeloid-derived lymphatic endothelial cells may exert a specific functional role, which may explain the need of only a low number of these cells for the complete process of lymphangiogenesis.
