Indeed, it has been proposed that these discordant functions of Wnt5a may affect CRC prognosis in a time-dependent manner, whereby early Wnt5a expression exerts a favourable effect by inhibiting tumour growth through canonical Wnt suppression, whereby late expression of Wnt5a exerts a deleterious effect by promoting tumour invasion through non-canonical Wnt activation (Wang, 2009).
Subjects harbouring p53−/BSI high lesions exerted a favourable prognosis as compared to p53−/BSI low or p53+/BSI low cases (5-year DFS 80.7 vs 45.5 or 50.4%; 5-year OS 80.8 vs 58.5 or 62.6%), whereas patients with the p53+/BSI high phenotype were observed to have an intermediate-risk profile (5-year DFS 61.9%; 5-year OS 70.9%).
In the multicenter ECOST trial, clinical reactions enabled by early detection resulted in a large reduction in the number of actually delivered shocks (−72%), the number of charged shocks (−76%), the rate of inappropriate shocks (−52%), and at the same time exerting a favourable impact on battery longevity.
Clearly, an intervention which might reduce the prevalence of MRSA has the potential to exert an extremely favourable impact on both patient outcomes and hospitalization costs.
A high expression of INHBA was associated with a favourable prognostic outcome, exerting a tumour suppressor and anti-angiogenic role in neuroblastoma patients (Schramm et al, 2005).
Although HER4 is known to potentially exert a tumour cell killing activity and in turn to have a favourable impact in breast cancer patients we demonstrate here the first time that HER4 expression prolongs overall survival in Herceptin-treated patients.
Creating a favourable environment: Taking into consideration the strong influence exerted by mass media upon young people, considerable attention in the programme was given to working with the press, radio and television: thematic workshops, conferences and contests were held for journalists; they provided coverage on social actions, etc.
Moreover, for the treatment of single atherosclerotic lesions, a local application might be a favourable option, given that local application using drug-eluting stents or balloons may exert potent effects with negligible systemic side effects.
(Not necessarily a favourable development).
"Mine is a favourable one.
