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Such genes could be located at the X or even the Y chromosome, for example on the X non-inactivated regions, and thus exert a dose effect differences among different groups of samples studied.
However, recent research conducted in our laboratory has provided experimental evidence to confirm that a decoction prepared from the aerial parts of this plant can exert a dose dependent cytotoxicity to AN3CA cells (derived from a hormone and chemotherapy resistant endometrial cancer), thus providing experimental support for the traditional use of F. leucopyrus for cancer therapy.
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To date, it has been found that CGRP-R antagonists exert a dose-dependent inhibitory effect on CSD.
Many algorithms reward microRNAs that have multiple binding sites within the 3' UTR of a particular gene, reasoning that the microRNAs will be able to exert a dose-dependent effect on target expression.
Also, icaritin has been reported to exert a dose-dependent effect on reducing the incidence of osteonecrosis with inhibition of intravascular thrombosis and extravascular lipid deposition (Zhang et al. 2009).
Our present results suggest that antipsychotic drugs exert a dose-dependent effect on ANS activity and decrease ANS activity significantly and that HRV power spectral analysis, as a diagnostic measurement of ANS, may allow for the identification of patients at high risk for sudden cardiac death.
Consistently, acute DPP-4 inhibition with vildagliptin was found to exert a dose-dependent protective effect on kidney function after IRI in a nondiabetic rat model, as indicated by a decrease of tubular necrosis and inhibition of the apoptotic pathway in the renal proximal epithelial cells.
Impedance measurement showed that oxLDL exerted a dose- and time-dependent reduction in cell viability.
According to the apoptosis measurements, doxorubicin exerted a dose dependent cytotoxic effect on HCC1143 and HCC1937 cells (p < 0.001).
We report here that direct inhibition of BRDT by a small-molecule bromodomain inhibitor exerts a dose- and time-dependent inhibitory effect on spermatogenesis.
Docetaxel and mitoxantrone exerted a dose dependent cytotoxic effect on DU145 cells with a maximum of about 50% cytotoxicity each (p < 0.001; Figure 4C F).
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