Sentence examples for exert a central from inspiring English sources

UPS function has been implicated to exert a central role in the pathogenesis of various human diseases.

Tradeoffs presumably exert a central role in life history evolution given that energy-limited organisms cannot simultaneously maximize all components of fitness.

Hence, mutations in TARDBP and FUS indicate that RBPs might exert a central role in the pathogenesis of FTLD/ALS-related disorders.

C3c may play a role in the development of air pollution related insulin resistance and type 2 diabetes, because epithelial cells and macrophages at the airway surface produce multiple components of the complement system that exert a central role in innate immunity (Cole et al. 1983; Strunk et al. 1988).

Within this cascade of events, CDK5 exerts a central role as a key regulator of neuronal death and survival [11].

The GHS-R1a has been implicated in Akt signaling, a serine/threonine kinase that exerts a central role in the regulation of metabolism, apoptosis, transcription and cell-cycle [7].

E-cadherin exerts a central role in epithelial homeostasis and its loss at the cell-cell junctions leads to reduced expression and/or organization of other epithelial markers including zona occludins-1 [8].

Our findings show that p21 exerts a central role in these effects.

MTTP exerts a central role in VLDL assembly and secretion [ 10].

Mapb1 exerts a central role in the process of axonal elongation and branching [ 40].

FAK exerts a central role on cell migration and invasion, and its activation is correlated with malignant transformation [ 37, 38].