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These results highly suggest that NOTCH can exert a cell autonomous effect on hemogenic endothelial cells destined to become HSPC.
However, Dll1 overexpression does exert a cell autonomous effect because it stimulates the spreading of individual keratinocytes on extracellular matrix [ 43].
On the basis of the lipid-binding cavity, another model was suggested wherein LTP could exert a cell wall-loosening effect on the cells of the secretory zone of the stigma.
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High-energy α particles and lithium ions have been shown to exert a cell-killing effect.
This fact suggests that the polyphenols present in cereal fractions could exert a cell-dependent effect on migration capacity.
In this study, we found that acute in vitro application of fluoxetine exerts a cell type-specific action in PFC, with a major impact on FS interneurons rather than pyramidal neurons.
Despite this, we can extrapolate from whether notch, through which zangptls signal, can exert in a cell autonomous fashion on the endothelial cells or HSPCs during hematopoiesis.
Notably, these mutant cells exert an increased cell traction force, an early cellular response during TGF β1-induced EMT.
Hydroxyurea exerts a cell-cycle-specific effect during early S-phase, through inhibition of ribonucleotide reductase, thereby blocking DNA synthesis (Kyritsis et al, 1996).
The lymphomagenic potential of AID was previously shown to be dampened in B cells (Muto et al, 2006; Robbiani et al, 2009), where p53 exerts a cell-intrinsic tumor suppressor function (Robbiani et al, 2009).
The level of loss of heterozygosity (LOH) that reduces a gene dose and exerts a cell-adverse effect is known to be a parameter for the genetic staging of gastric cancers.
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