Formation of MCGs will be aided by the affinity clustering technique [ 54, 67], which can be employed in large samples and has the advantage of identifying an "exemplar" patient whose variables represent those of the MCG members, thus making it possible to characterize MCGs at the analysis stage.
A questionnaire was designed to elicit requests, with scenarios derived through exemplar generation and variable values arrived at through two rounds of metapragmatic assessment.
We did not evaluate other popular approaches that do not use information on the source of unwanted variation, the exemplar being surrogate variable analysis, or simpler methods as regressing with the principal components, as the main focus here was highlighting the requirement for batch effect correction, rather than evaluating methods.
Figure 8(A) shows the free RNA polymerase (RNAp, s001) where, although the number of total molecules is fairly large (301 in this exemplar model), the state variable can only fluctuate between 301 and 297 molecules corresponding to zero or four polymerase molecules bound to the promoter and start sites of the two genes.
That is, a set of abstract, phonological features allows the identification of acoustically quite variable exemplars of classes of speech sounds.
This disease was selected as an exemplar because the clinical onset is variable, the diagnosis is often uncertain in the early stages and early intervention with disease modifying anti-rheumatic drugs (DMARD) has been shown to improve prognosis [ 14].
The selection of variable sites for inclusion in genomic analyses can influence results, especially when exemplar populations are used to determine polymorphic sites.
The effects of five new different handle shapes on hand performance capabilities, usability and discomfort, and also the relationship between these variables were evaluated in the context of masonry work and using masons' trowels as an exemplar hand tool.
Analysis of the relationship between "influences" and "receptivity" variables revealed that the most important factors explaining this relationship are "mimetic", related to the influence of other exemplar PHC organizations.
Not an exemplar — the exemplar.
