This article describes the development and adoption of the UK rehabilitation outcomes collaborative (UKROC) data set in one exemplar setting.
Using Arabidopsis thaliana as an exemplar, a set of 40 Sequence Tagged Site (STS) markers spanning ∼10% of chromosome 4 were simultaneously assembled onto a BAP map compiled using both a series of BAC pools each comprising 0.7x genome coverage and dilute (0.7x genome) samples of sheared genomic DNA.
Data were drawn together to provide an exemplar indicator set a single network, and methods of graphical presentation were considered.
The gene listed associated with the ChIP-seq peaks for each TF were compared to the exemplar gene set for each PhyloNet motif and significance of the overlap determined by a Fisher exact test.
We then discuss the capabilities of the procedure and provide guidelines for interpreting results using exemplar data sets.
In what follows we describe the application of PCO-MC to four exemplar data sets with varying levels of genetic subdivision, from highly structured to virtually unstructured.
Using a stringency cutoff of P < 0.05 after correction for multiple tests, we determined that 682 (13.75%) exemplar gene sets exhibit similar expression patterns in at least one experimental condition, suggesting a regulatory function of that associated PWM (see Table S1 for the complete list).
We compared the exemplar gene sets for each of the PhyloNet PWMs with the GO annotation, at a stringent significance threshold (P < 0.05 after correction for multiple tests), to find that 3676 (74%) are significantly enriched for at least one biological function.
To most people he's repugnant, but to his peers he's a formidable exemplar of a set of skills that have come to flourish in the era of online bile, useful only to those whose primary aim is destructive and reductive.
The smells, the intricate design, the exemplar Walt Disney set, the idea of reaching for perfection, seeing children with their parents and stupid teenagers on dates.
