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Exemplar compounds from each of the five chemical series showed reduced potency at the higher concentration of ATP, indicative of ATP competitive behavior (Table 2).
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Lines join compounds in a cluster to a central "exemplar" compound as determined by the AP algorithm (see methods).
The synthesis of selected exemplar screening compounds is also described.
The time to reach peak ALT/AST values was much faster with Entolimod than with previous exemplar hepatotoxic compounds modeled (e.g., acetaminophen, furosemide, aflatoxin).
Exemplars of predicted compound binding site interactions compared with rimantadine are shown (Fig. 4C).
The 'cromoglycate-like' anti-allergic drugs (cromolyns) are a group of compounds of which sodium cromoglycate and sodium nedocromil are the exemplars.
Compounds were evaluated in a cell-based functional mGlu5 assay, and an exemplar analog 27 was >60-fold selective versus the other seven mGlu receptors.
Using Cofilin1 as an exemplar, we sought to determine if there might be specific or general modes used by cucurbitacin compounds to interact with target proteins, and by inference whether these compounds could potentially be optimized for potency and selectivity.
The single clade, comprising exemplars of Funaria with a compound annulus, is congruent with the systematic concept proposed by Fife (1985).
Not an exemplar — the exemplar.
Ethics exemplar.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com