Caspases are broadly categorized into initiators (caspase-2, -8, -9, -10), effectors or executioners (caspase-3, -6, -7), and inflammatory caspases (caspase-1, -4, -5).
Apoptotic initiators, such as caspases-8, -9 and -10, activated procaspases-3 and -7 by specific hydrolysis, thereby triggering cell death by specific apoptotic executioners [ 1, 6, 7].
Apoptosome formation leads to the activation of executioner caspase-3, −6 and −7 [ 26].
Following activation of either the intrinsic or extrinsic pathways of the apoptotic cascade, initiator caspases cleave and activate the executioner caspases-3, -6 or -7.
Recently, it was reported that executioner caspases-3, 6, and 7 play non-redundant roles during the demolition phase of apoptosis.
It executes cellular apoptosis by activating executioner caspases (-3, -6 and -7), as well as through the intrinsic pathway by cleaving the BID protein.
There are about 27 hours' worth of television in the footage of Storyville's Pol Pot's Executioner (BBC4).
The Executioner -10g Sacrifice 10 people in the Temple of Shadows.
Tuesday, Sept. 15 "The Mindy Project" (Hulu) "Bastard Executioner" 10 00 p.m. ET (FX) "Best Time Ever With Neil Patrick Harris" 10 00 p.m. ET (NBC).
The stimulation of hemocytes with LPS, LTA and CPGs induced up-regulation of both initiator (-2 and -8) and executioner (-3/7-1 and -3/7-2) caspases.
Various caspases, including the subfamily of inflammatory mediator (CASP1, CASP4), the apoptotic activator (CASP2, CASP8) and the apoptotic executioner (CASP7) [ 17- 19] were up-regulated in response to infection.
