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Therefore, the actual execution of trials and the epidemiology of HHF populations at the investigative sites must be taken into consideration.
Just as lupus is a multisystem disease, the design and execution of trials should be multidisciplinary.
Effective recruitment to clinical trials is critical to the successful execution of trials; however about 38% of cancer clinical trials (CCT) fail to meet minimum accrual goals [ 16].
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This chapter reviews strategies used in the development and execution of clinical trials, and explains why trials may have failed to reveal well-founded evidence and how future trials can be designed to better find new treatment modalities.
The design and execution of prevention trials for OA have methodological issues that are distinct from trials designed to impact prevalent disease.
The major obstacles for a human CMV vaccine are difficulties associated with the design and execution of efficacy trials.
This information should help in the design and execution of clinical trials focused on dystrophin restoration strategies.
She is a leader in the design and execution of clinical trials of new treatments for infections that have significantly improved the outcomes of high-risk patients.
Design and execution of clinical trials in the CLI population are challenging, in part because of the lack of consensus on cohort definitions and relevant endpoints.
As a consequence of flaws in the design and the execution of the trials, statistical significance is quite often not equal to clinical relevance.
Sponsors and investigators must accept responsibility for optimizing the design and execution of clinical trials, and practitioners, guidelines committees, editors, and regulators must critically interpret the data and literature arising from such studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com