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The funders had no role in the execution of this study or interpretation of the results.
Wittes hailed the trial as definitive and claimed, "It is difficult to find fault with the design or execution of this study.
In the design and execution of this study, there are several considerations that need to be taken into account as they can potentially limit the validity of the results obtained.
All authors of this manuscript have directly participated in the planning and execution of this study, and therefore, we confirm that the manuscript has been read and approved by all named authors.
However, this turns out to be far from the complete picture: the execution of this study has shown that the careful operation of a DSC, with the attention needed to the calibration of the heat flow and heat capacity at low scanning rates consumes an enormous amount of manpower and time.
We also thank Roberta Halpenny and the staffs of the Maple Leaf Clinic and the National Institute of Allergy and Infectious Diseases HIV Clinic for their invaluable assistance in the execution of this study.
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NS participated in the study protocol, overall design and execution of the study, first drafted this manuscript.
A videotutorial for installation and execution of this case study is available at https://www.youtube.com/watch?v=eKpf-K2T8hw.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2334/13/609/prepub Many individuals generously provided time, expertise and resources that were essential in the development and execution of this research study.
RTI International is acknowledged for supporting the time of Susan McRitchie, Keeley Pratt and Susan Sumner to participate in the design, execution, or analysis of this study.
The funding agencies were not involved in the design, execution and reporting of this study.
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