Exact(12)
Interestingly, signaling pathways required for the initiation and execution of programmed cell death, or apoptosis, are activated during myogenesis [4], [5].
Furthermore, MIP supernatant induced MMP and subsequent release of AIF and cytochrome c into the cytoplasm and further translocation of AIF into the nucleus, as observed, may be the key discrete events responsible for the execution of programmed cell death of mouse peritoneal macrophages.
These protein kinases were previously shown to be important for the execution of programmed cell death after toxic stimuli [ 26].
Caspase-3, also known as the death enzyme, has a crucial role in the controlled execution of programmed cell death.
In apoptosis, proteolysis by caspases is the primary mechanism for both initiation and execution of programmed cell death (PCD).
In plants, the prominent role of reactive oxygen species (ROS) has been revealed in induction, signaling, and execution of programmed cell death (PCD) [ 47].
Similar(48)
CED-4 translocation induced by the cell-death activator EGL-1 was blocked by a gain-of-function mutation in ced-9 but was not dependent onced-3 function, suggesting that CED-4 translocation precedes caspase activation and the execution phase of programmed cell death.
The discovery of the translocation of MLKL complex to plasma membrane sheds light on the execution mechanisms of programmed necrosis.
Previous studies have shown that the cleavage of PARP, a hallmark of apoptosis, occurs during the execution phase of programmed cell death [ 49].
This guarantees correct execution of the program.
In plants, attempted microbial invasion triggers the hypersensitive response, a programmed execution of plant cells at the sites of infection.
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