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Our aim was to determine whether ballooned hepatocytes have potentially disabled the cell death execution machinery, and if so, can their functional biology be modeled in vitro.
The central execution machinery primarily consists of caspases, a family of cysteine proteases that function as a signaling cascade in the death process [ 41].
The immunohistochemical staining of components of the execution machinery of apoptosis, such as activated caspase 3, have been assessed as surrogates for apoptosis itself with variable success [ 3, 4].
Because induction of apoptosis involves complex interactions between many signaling pathways and arrangement of the highly sophisticated execution machinery of cell death, diverse antitumor strategies have been proposed to affect these interactions to preferentially kill tumor cells while sparing normal cells (1– 5).
We show herein that HeLa-APL cells had intact response to a number of caspase-dependent death inducers like doxorubicin, camptothecin, paclitaxel or etoposide, and therefore most likely had an intact apoptosis execution machinery, further indicating that the alteration was upstream of caspase activation.
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We follow Joe de Rocher through the corridors and anterooms of Angola Prison as failed legal appeals and the machinery of execution take him gradually to his death.
Instead, what businesses need help with in fact is the polar opposite: not the forklifting but the unpacking of Uber to identify the two or three most applicable elements from its operating machinery and growth execution that can spark transformative opportunities in your industry.
Elucidation of the underlying protein machinery responsible for the execution of PCD in P. falciparum will provide insight into the working of active cell death and the complex interactions between parasite and host.
Ground properties influence various aspects of mobile machinery navigation including localization, mobility status or task execution.
While the initiation of apoptosis by the receptor complex and the execution via the mitochondrial pathway constitute two parts of the machinery, several other pathways affect the apoptotic process dramatically.
The last step, process of substrate digestion, requires lysosome degradative machinery, and hence autophagosomes fuse with lysosome for the execution phase of autophagy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com