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Since ENVOY comprises no known DNA-binding domain, it likely does not directly bind to DNA, and therefore executes its function via interaction with downstream regulatory proteins targeting the respective pathways.
A set of techniques is applied in order to be possible the system executes its function: fuzzy logic, neural network, genetic algorithm and statistic analysis.
These results clearly demonstrate that Par-1 executes its function in the COC mainly through phosphorylation of Baz.
The epigenetic gene-silencing machinery in the cell executes its function via efficient co-ordination between the two main protagonists - DNMT and MBD proteins.
The majority of MIR2911 in mouse peripheral blood was detected in MV fraction, and MIR2911 in the MVs was largely associated with the AGO2 complex, supporting that MIR2911 executes its function through the same MV-mediated pathway.
Notwithstanding these tentative explanations, a further and more detailed study raising these questions is required in order to uncover the exact mechanism by which c-Abl executes its function in DSB repair downregulation.
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This was very surprising since H executes its functions solely through protein-protein interactions.
These results are consistent with the notion that CTGF executes its functions through integrins [ 62- 64], and with a previous hypothesis that CTGF is a mediator of pro-fibrotic responses to TGFβ [ 65].
It may execute its function by modulating or interacting with other cell cycle effectors, ultimately leading to unchecked cell proliferation and malignant transformation.
Rather than speculate, we simply state that syt 7 must execute its function from where it is located: at the plasma membrane, or on internal vesicles that likely correspond to LDCVs and lysosomes.
Using cell-free and cell-based approaches we showed that Ciz1 stimulates initiation of DNA replication in late G1 phase nuclei [ 5] and that it cooperate with cyclin E and A in order to execute its function in DNA replication [ 2].
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