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This protein platform activates caspase-9 and later caspase-3, initiating the caspase cascade, which executes cell death in an orchestrated way7,8.
Cytochrome c triggers the caspase-dependent cascade [ 27], but AIF executes cell death in the absence of caspase [ 28- 30].
In higher eukaryotes and certain archaea, but not in budding yeast, the ESCRT machinery also executes cell abscission, the final membrane scission step that terminates cytokinesis.
Similar to caspase-8, the initiator caspase-9 triggers activation of the effector caspase-cascade that finally executes cell death [ 17- 19].
It is unclear how autophagy executes cell death; however, recent reports have implicated autophagy-mediated activation of CASP8 as a possible mechanism.
A plant-specific microtubular preprophase band (PPB) accurately predicts the line of cell division, whereas the phragmoplast, another plant-specific array, executes cell division by maintaining this predicted line.
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Thus, how JNK executed cell elimination remained elusive.
Prodeath molecules orchestrate around mitochondria to initiate and execute cell death in cancer, and also play an underappreciated role in survival of cancer cells.
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that integrates nutrients to execute cell growth and protein synthesis.
The assumption that every organelle is capable of sensing, amplificating and executing cell death is also a relatively novel and unexplored concept.
The increases in survival exhibited by ES cells deficient in DNA mismatch repair appeared to have resulted from a failure to efficiently execute cell death (apoptosis) in response to radiation exposure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com