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We designed and executed this study to current rigorous standards for biomarker clinical studies [21] [23] with the goals of maximize biomarker robustness, validity, and reliability at the discovery phase, and minimizing potential effects of preanalytical variability.
SM executed this study, conducted analysis and wrote this manuscript.
SCL executed this study and wrote the draft of this manuscript.
HTC and SCL executed this study and prepared the draft of the manuscript.
Submitting authors conceived, designed and executed this study and wrote the manuscript.
YN, MD and PD jointly conceived and executed this study, and helped draft the manuscript.
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However, while people with I/DD made valuable contributions to the focus groups, there were several modifications needed in order to execute this study.
By executing this study, we experienced that including patients after an exacerbation of COPD is very difficult.
Ethical considerations were taken into account when designing and executing this study and the ethics board of the Janbazan (veterans) Medical and Engineering Research Center approved the project.
We thank the Center for Genomics and Bioinformatics at Indiana University and its staff, especially Keithanne Mockaitis and John Colborne for their help and expertise in executing this study.
In the interests of simplicity as a pilot, and so as to execute this study within the parameters of normal clinic operations based on existing guidelines and tools, we selected only a few of the most important variables for investigation.
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