Locally appropriate reference intervals are essential for planning and executing trials in a safe, efficient and ethical manner.
The number of executed trials during testing procedure varied due to EEG quality and EEG-vigilance regulation patterns [ 31].
44 Based on the meagre results from our extensive systematic review, we conclude that there is an urgent need for well designed and well executed trials of treatment for adults who commit sexual offences against children.
In order to identify previously executed trials of interventions targeted at the management of hypertension and/or elevated cholesterol in general practice, the trial register of the Cochrane Group of Effective Practice and Organisation of Care EPOCC) was searched in July 2001 (See Additional File 1: Appendix) [ 20].
To ensure that reversal shifts were unpredictable and that subjects had established a specific response set prior to a reversal we set a minimum constraint of 5 correctly executed trials (10 before the first reversal switch) per contingency before a possible reversal, after which there was a 50% probability of a reversal per trial.
A poorly designed or executed trial can therefore lead researchers to erroneous conclusions about the effectiveness of a drug or a procedure.
We also execute clinical trials with millions of dollars worth of experimental treatments provided for free to our courageous participants.
Patient numbers are the obvious challenge in a rare cancer, but collaborations across institutes and countries are making it feasible to execute such trials and focus on pathogenesis-driven therapies in some rare subtypes.
Finally, it may be more difficult to design and execute clinical trials that attempt to prove a principle and may have little or no therapeutic benefit for the participants, the simplest example being pharmacokinetic/pharmacodynamic studies in humans.
